Transgenic animal mutagenicity assays /
Transgenic animal mutagenicity assays /
first draft prepared by Ulrich Wahnschaffe ... [et al.].
- Geneva : World Health Organization, 2006.
- xxv, 298 p. : ill.
- Environmental health criteria, 233 0250-863X ; .
- Environmental Health Criteria; 233 .
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." "International Programme on Chemical Safety"--Cover.
Includes bibliographical references (p. 179-214).
pt.1. Overview of genotoxicity testing and transgenic animal mutagenicity systems -- pt. 2. Comparison of the LACI model and the LACZ model with conventional test systems -- pt. 3. Applications of transgenic animal mutagenicity studies -- pt. 4. Evaluation, conclusions and recommendations.
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.
9789241572330 9241572337
Prueba de la mutagenicidad.
Mutagenicity Tests.
Animales, geneticamente modificados.
Animals, Genetically Modified--genetics.
Mutagen--Toxicidad.
Mutagens--toxicity.
Gravamen de riesgo.
Risk Assessment.
Prueba de la mutagenicidad.
Mutagenicity testing.
Animales transgenicos.
Transgenic animals.
Toxicología genetica.
Genetic toxicology.
Gravamen de riego de salud.
Health risk assessment.
Mutagênese (testes)
Camundongos (genética)
Medição de risco.
Exposição ambiental.
RA1224.4.M86 / T73 2006
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." "International Programme on Chemical Safety"--Cover.
Includes bibliographical references (p. 179-214).
pt.1. Overview of genotoxicity testing and transgenic animal mutagenicity systems -- pt. 2. Comparison of the LACI model and the LACZ model with conventional test systems -- pt. 3. Applications of transgenic animal mutagenicity studies -- pt. 4. Evaluation, conclusions and recommendations.
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.
9789241572330 9241572337
Prueba de la mutagenicidad.
Mutagenicity Tests.
Animales, geneticamente modificados.
Animals, Genetically Modified--genetics.
Mutagen--Toxicidad.
Mutagens--toxicity.
Gravamen de riesgo.
Risk Assessment.
Prueba de la mutagenicidad.
Mutagenicity testing.
Animales transgenicos.
Transgenic animals.
Toxicología genetica.
Genetic toxicology.
Gravamen de riego de salud.
Health risk assessment.
Mutagênese (testes)
Camundongos (genética)
Medição de risco.
Exposição ambiental.
RA1224.4.M86 / T73 2006
