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04456nam a22004575i 4500 |
| 001 - NÚMERO DE CONTROL |
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| 003 - IDENTIFICADOR DEL NÚMERO DE CONTROL |
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SIRSI |
| 005 - FECHA Y HORA DE LA ULTIMA TRANSACCIÓN |
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20160812084053.0 |
| 007 - CAMPO FIJO DE DESCRIPCIÓN FIJA--INFORMACIÓN GENERAL |
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cr nn 008mamaa |
| 008 - ELEMENTOS DE LONGITUD FIJA -- INFORMACIÓN GENERAL |
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110811s2011 xxu| s |||| 0|eng d |
| 020 ## - NÚMERO INTERNACIONAL NORMALIZADO PARA LIBROS |
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| International Standard Book Number |
9781441999405 |
| -- |
978-1-4419-9940-5 |
| 040 ## - FUENTE DE CATALOGACIÓN |
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| Transcribing agency |
MX-MeUAM |
| 050 #4 - SIGNATURA TOPOGRÁFICA DE LA BIBLIOTECA DEL CONGRESO |
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| Classification number |
RC321-580 |
| 082 04 - NÚMERO DE CLASIFICACIÓN DECIMAL DEWEY |
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| Classification number |
612.8 |
| Edition number |
23 |
| 100 1# - ASIENTO PRINCIPAL--NOMBRE PERSONAL |
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| Personal name |
Farooqui, Akhlaq A. |
| Relator term |
author. |
| 245 10 - MENCIÓN DE TITULO |
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| Title |
Lipid Mediators and Their Metabolism in the Brain |
| Medium |
[recurso electrónico] / |
| Statement of responsibility, etc. |
by Akhlaq A. Farooqui. |
| 250 ## - MENCIÓN DE EDICIÓN |
|---|
| Edition statement |
1. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
New York, NY : |
| Name of producer, publisher, distributor, manufacturer |
Springer New York, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2011. |
| 300 ## - DESCRIPCIÓN FÍSICA |
|---|
| Extent |
XXIV, 327p. 103 illus., 63 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS |
|---|
| File type |
text file |
| Encoding format |
PDF |
| Source |
rda |
| 505 0# - NOTA DE CONTENIDO |
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| Formatted contents note |
Chapter 1. Metabolism and roles of eicosanoids in brain -- Chapter 2. Recent Developments on the neurochemistry of docosanoids -- Chapter 3. Metabolism, roles, and involvement of lyso-glycerophospholipids in neurological disorders -- Chapter 4. Platelet activating factor in brain: its metabolism, roles and involvement in neurological disorders -- Chapter 5. Cannabinoids in the brain: their metabolism, roles, and involvement in neurological disorders -- Chapter 6. Neurochemical aspects of 4-hydroxynonenal -- Chapter 7. Isoprostanes and other non-enzymic polyunsaturated fatty acid-derived lipid mediators in the brain -- Chapter 8. Ceramide and ceramide 1-phosphate in the brain -- Chapter 9. Sphingosine and sphingosine 1 phosphate in brain -- Chapter 10. Cholesterol and hydroxycholesterol in the brain -- Chapter 11. Perspective and direction for future research on lipid mediators. |
| 520 ## - NOTA DE RESUMEN, ETC. |
|---|
| Summary, etc. |
Lipid mediators are chemical messengers that are formed in response to cell stimulation or injury from membrane phospholipids, sphingolipid, and cholesterol. They play important roles in internal and external communication and modulate cellular responses such as the growth arrest, differentiation, adhesion, and migration. Lipid mediators of arachidonic acid (ARA) metabolism include prostaglandins, leukotrienes, thromboxanes, lipoxins, whereas lipid mediators of docosahexaenoic acid (DHA) metabolism are resolvins, protectins, neuroprotectins, and maresins. The non-enzymic lipid mediators of ARA and DHA metabolism include isoprostanes, neuroprostanes, isoketals, neuroketals, isofurans, neurofurans, 4-hydroxynonenal, and 4-hydroxyhexanal. Ceramide, ceramide 1-phosphate, sphingosine, and sphingosine 1-phosphate are lipid mediators of sphingolipid metabolism. These mediators are closely associated with apoptotic cell death, cell proliferation, cell migration, and survival. Cholesterol-derived mediators include 24-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, and 22-hydroxycholesterol. These mediators act as ligands of liver X receptors, transcription factors with key roles in lipid metabolism. Under normal conditions, low levels of lipid mediators are needed for signal transduction, gene expression, and neural cell proliferation and differentiation, but high levels of enzymic and non-enzymic lipid mediators of glycerophospholipid, sphingolipid, and cholesterol metabolism produce neurodegeneration through the induction of oxidative stress, neuroinflammation and synaptic dysfunction. Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain. |
| 596 ## - |
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| -- |
19 |
| 650 #0 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
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| Topical term or geographic name as entry element |
Medicine. |
| 650 #0 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
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| Topical term or geographic name as entry element |
Neurosciences. |
| 650 #0 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
|---|
| Topical term or geographic name as entry element |
Neurochemistry. |
| 650 #0 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
|---|
| Topical term or geographic name as entry element |
Neurology. |
| 650 14 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
|---|
| Topical term or geographic name as entry element |
Biomedicine. |
| 650 24 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
|---|
| Topical term or geographic name as entry element |
Neurosciences. |
| 650 24 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
|---|
| Topical term or geographic name as entry element |
Neurology. |
| 650 24 - ASIENTO SECUNDARIO DE MATERIA - TERMINO TEMÁTICO |
|---|
| Topical term or geographic name as entry element |
Neurochemistry. |
| 710 2# - ASIENTO SECUNDARIO - NOMBRE CORPORATIVO |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9781441999399 |
| 856 40 - LOCALIZACIÓN Y ACCESO ELECTRÓNICOS |
|---|
| Public note |
Libro electrónico |
| Uniform Resource Identifier |
<a href="http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-9940-5">http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-9940-5</a> |
| 942 ## - TIPO DE MATERIAL (KOHA) |
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| Koha item type |
Libro Electrónico |
