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06221nam a22005295i 4500 |
| 001 - CONTROL NUMBER |
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978-3-319-30705-3 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20180206183008.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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161013s2016 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783319307053 |
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978-3-319-30705-3 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH573-671 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSF |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI017000 |
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bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI049000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
571.9453 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Redox-Active Therapeutics |
| Medium |
[recurso electrónico] / |
| Statement of responsibility, etc. |
edited by Ines Batini?-Haberle, Júlio S. Rebouças, Ivan Spasojevi?. |
| 264 #1 - |
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Cham : |
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Springer International Publishing : |
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Imprint: Springer, |
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2016. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XXX, 694 p. 162 illus., 124 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 490 1# - SERIES STATEMENT |
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| Series statement |
Oxidative Stress in Applied Basic Research and Clinical Practice, |
| International Standard Serial Number |
2197-7224 |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Part 1. Pathophysiological Roles of Superoxide Dismutases (SOD) -- Superoxide and the Superoxide Dismutases: An Introduction by Irwin Fridovich -- The Discovery of Superoxide Dismutase and Its Role in Redox Biology -- Manganese Superoxide Dismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer -- Regulation of the Cellular Redox Environment by Superoxide Dismutases, Catalase and Glutathione Peroxidases During Tumor Metastasis -- Superoxide Dismutase Family of Enzymes in Brain Neurogenesis and Radioprotection -- Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment -- Part 2. Redox-Active Therapeutics ? Design and Mechanisms of Action -- Mimicking SOD, Why and How: Bio-Inspired Manganese Complexes as SOD Mimics -- Mn Porphyrin-Based Redox-Active Therapeutics -- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mn porphyrins as Redox Modulators -- Nitrones as Potent Anticancer Therapeutics -- Salen Manganese Complexes Mitigate Radiation Injury in Normal Tissues Through Modulation of Tissue Environment -- Molecular Basis for Anticancer and Antiparasite Activities of Copper-Based Drugs -- Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism -- HNO/Thiol Biology as a Therapeutic Target -- Part 3. Redox-Active Therapeutics in Cancer -- Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents -- Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells -- Targeted Therapy for Malignant Brain Tumors -- Redox Therapeutics in Breast Cancer: Role of SOD Mimics -- Anticancer Action of Mn porphyrins in Head and Neck Cancers -- Redox-based Therapeutic Strategies in the Treatment of Skin Cancers -- Role of Oxidative Stress in Erectile Dysfunction after Prostate Cancer Therapy -- Theranostic Nanoconjugates of Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy -- Part 4. Redox-Active Therapeutics in Other Diseases -- Quantum Dots in Photodynamic Therapy -- Metalloporphyrins in CNS injuries -- The Contribution of Nitroxidative Stress to Pathophysiological Pain and Opioid Analgesic Failure -- Amyotrophic Lateral Sclerosis ? Present Understanding of the Role of SOD -- Redox Regulation and Misfolding of SOD1: Therapeutic Strategies for Amyotrophic Lateral Sclerosis -- Redox-Based Therapeutics for Prevention, Mitigation, and Treatment of Lung Injury Secondary to Radiation Exposure -- Using Metalloporphyrins to Preserve ? Cell Mass and Inhibit Immune Responses in Diabetes -- Redox-Active Metal Complexes in Trypanosomatids. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer (such as the role of mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. The second section encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Subsequent sections and chapters describe more specialized aspects of redox-active therapeutics in clinical disorders, such as cancer, cardiovascular diseases, diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer´s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome?the organism redox network?as an emerging frontier in drug design, redox biology and medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Enzymology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Oxidative stress. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Oxidative Stress. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Enzymology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Término temático o nombre geográfico como elemento de entrada |
Cancer Research. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Batini?-Haberle, Ines. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rebouças, Júlio S. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Spasojevi?, Ivan. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Relationship information |
Printed edition: |
| International Standard Book Number |
9783319307039 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Oxidative Stress in Applied Basic Research and Clinical Practice, |
| -- |
2197-7224 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Public note |
Libro electrónico |
| Uniform Resource Identifier |
http://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-30705-3 |
| 912 ## - |
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ZDB-2-SBL |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Libro Electrónico |
