The Glutamate/GABA-Glutamine Cycle (Registro nro. 227835)

MARC details
000 -LIDER
fixed length control field 04231nam a22004575i 4500
001 - CONTROL NUMBER
control field 978-3-319-45096-4
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20180206183136.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 161125s2016 gw | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783319450964
-- 978-3-319-45096-4
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RC321-580
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSAN
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED057000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.8
Edition number 23
245 14 - TITLE STATEMENT
Title The Glutamate/GABA-Glutamine Cycle
Medium [recurso electrónico] :
Remainder of title Amino Acid Neurotransmitter Homeostasis /
Statement of responsibility, etc. edited by Arne Schousboe, Ursula Sonnewald.
264 #1 -
-- Cham :
-- Springer International Publishing :
-- Imprint: Springer,
-- 2016.
300 ## - PHYSICAL DESCRIPTION
Extent X, 416 p. 55 illus., 42 illus. in color.
Other physical details online resource.
336 ## -
-- text
-- txt
-- rdacontent
337 ## -
-- computer
-- c
-- rdamedia
338 ## -
-- online resource
-- cr
-- rdacarrier
347 ## -
-- text file
-- PDF
-- rda
490 1# - SERIES STATEMENT
Series statement Advances in Neurobiology,
International Standard Serial Number 2190-5215 ;
Volume/sequential designation 13
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Introduction to the Glutamate-Glutamine cycle -- Glucose, lactate, ?-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle -- Anaplerosis for glutamate synthesis in the neonate and in adulthood -- Enzyme complexes important for the glutamate-glutamine cycle -- BCAA metabolism and NH3 homeostasis -- Glutaminases Vesicular Glutamate Uptake -- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle -- Glutamine Metabolism in Gliomas -- Oligodendrocytes: development, physiology and glucose metabolism -- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity -- Astroglia, glutamatergic transmission and psychiatric diseases -- Glutamine Synthetase: Role in Neurological Disorders -- The Glutamate ? Glutamine Cycle in Epilepsy -- Index.
520 ## - SUMMARY, ETC.
Summary, etc. Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term ?The Glutamate-Glutamine Cycle.? In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Término temático o nombre geográfico como elemento de entrada Medicine.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Término temático o nombre geográfico como elemento de entrada Neurosciences.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Término temático o nombre geográfico como elemento de entrada Biomedicine.
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM
Término temático o nombre geográfico como elemento de entrada Neurosciences.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Schousboe, Arne.
Relator term editor.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sonnewald, Ursula.
Relator term editor.
710 2# - ADDED ENTRY--CORPORATE NAME
Corporate name or jurisdiction name as entry element SpringerLink (Online service)
773 0# - HOST ITEM ENTRY
Title Springer eBooks
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Printed edition:
International Standard Book Number 9783319450940
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Advances in Neurobiology,
-- 2190-5215 ;
Volume number/sequential designation 13
856 40 - ELECTRONIC LOCATION AND ACCESS
Public note Libro electrónico
Uniform Resource Identifier http://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-45096-4
912 ## -
-- ZDB-2-SBL
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Libro Electrónico
Existencias
Estado de retiro Colección Ubicación permanente Ubicación actual Fecha de ingreso Total Checkouts Date last seen Número de copia Tipo de material
  Colección de Libros Electrónicos Biblioteca Electrónica Biblioteca Electrónica 06/02/2018   06/02/2018 1 Libro Electrónico

Con tecnología Koha