MARC details
| 000 -LIDER |
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| fixed length control field |
05032nam a22005535i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-981-13-1912-9 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20210201191328.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
181208s2018 si | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9789811319129 |
| -- |
978-981-13-1912-9 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RS380 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RS190-210 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
TDCW |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED072000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
TDC |
| Source |
thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
615.19 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis of Therapeutic Oligonucleotides |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc. |
edited by Satoshi Obika, Mitsuo Sekine. |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
1st ed. 2018. |
| 264 #1 - |
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| -- |
Singapore : |
| -- |
Springer Singapore : |
| -- |
Imprint: Springer, |
| -- |
2018. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
VIII, 284 p. 208 illus., 35 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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| -- |
text |
| -- |
txt |
| -- |
rdacontent |
| 337 ## - |
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| -- |
computer |
| -- |
c |
| -- |
rdamedia |
| 338 ## - |
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| -- |
online resource |
| -- |
cr |
| -- |
rdacarrier |
| 347 ## - |
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| -- |
text file |
| -- |
PDF |
| -- |
rda |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Acceso multiusuario |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Part 1. Synthesis of Natural Oligonucleotides -- Chapter 1. Non-protected Synthesis of Oligonucleotides -- Chapter 2. Various Coupling Agents in the Phosphoramidite Method for Efficient Oligonucleotide Synthesis -- Chapter 3. Recent Development of Chemical Synthesis of RNA -- Chapter 4. RNA Synthesis Using the CEM Group -- Chapter 5. Liquid-Phase Synthesis of Oligonucleotides -- Chapter 6. Large-Scale Oligonucleotide Manufacturing -- Part 2: Synthesis and Properties of Artificial Oligonucleotides -- Chapter 1. Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modified Nucleobases -- Chapter 2. Site-Specific Modification of nucleobases in oligonucleotides -- Chapter 3. Four-Hydrogen-Bonding Base Pairs in Oligonucleotides: Design, Synthesis, and Properties -- Chapter 4. Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Property of 3-Cyanovinylcarbazole-modified Nucleic Acids and Its Photo-induced Gene-Silencing Activity in Cells -- Chapter 5. Effects of 2´-O-Modifications on RNA Duplex Stability -- Chapter 6. 2',4'-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moiety -- Chapter 7. Synthesis and Therapeutic Applications of Oligonucleotides Containing 2'-O,4'-C-Ethylene- and 3'-O,4'-C-Propylene-Bridged Nucleotides -- Chapter 8. RNA Bioisosters: Chemistry and Properties of 4'-ThioRNA and 4'-SelenoRNA -- Chapter 9. Development of Triplex Forming Oligonucleotide including Artificial Nucleoside Analogues for the Antigene Strategy -- Chapter 10. Chemical Synthesis of Boranophosphate Deoxyribonucleotides. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research. |
| 541 ## - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Owner |
UABC ; |
| Method of acquisition |
Temporal ; |
| Date of acquisition |
01/01/2021-12/31/2023. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Término temático o nombre geográfico como elemento de entrada |
Pharmaceutical technology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Término temático o nombre geográfico como elemento de entrada |
Medicinal chemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Término temático o nombre geográfico como elemento de entrada |
Molecular biology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Término temático o nombre geográfico como elemento de entrada |
Pharmaceutical Sciences/Technology. |
| -- |
https://scigraph.springernature.com/ontologies/product-market-codes/B21010 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Término temático o nombre geográfico como elemento de entrada |
Medicinal Chemistry. |
| -- |
https://scigraph.springernature.com/ontologies/product-market-codes/C28000 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Término temático o nombre geográfico como elemento de entrada |
Molecular Medicine. |
| -- |
https://scigraph.springernature.com/ontologies/product-market-codes/B1700X |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Obika, Satoshi. |
| Relator term |
editor. |
| Relator code |
edt |
| -- |
http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sekine, Mitsuo. |
| Relator term |
editor. |
| Relator code |
edt |
| -- |
http://id.loc.gov/vocabulary/relators/edt |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9789811319112 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Printed edition: |
| International Standard Book Number |
9789811319136 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Public note |
Libro electrónico |
| Uniform Resource Identifier |
http://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-981-13-1912-9 |
| 912 ## - |
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| -- |
ZDB-2-SBL |
| 912 ## - |
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| -- |
ZDB-2-SXB |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Libro Electrónico |
