p53 [recurso electrónico] / by Ayeda Ayed, Theodore Hupp.

Por: Ayed, Ayeda [author.]Colaborador(es): Hupp, Theodore [author.] | SpringerLink (Online service)Tipo de material: TextoTextoSeries Molecular Biology Intelligence Unit ; 1Editor: Boston, MA : Springer US : Imprint: Springer, 2010Descripción: XVI, 200p. 59 illus., 3 illus. in color. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9781441982315Tema(s): Medicine | Oncology | Biomedicine | Cancer ResearchFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 614.5999 Clasificación LoC:RC261-271Recursos en línea: Libro electrónicoTexto
Contenidos:
TP53 Mutations in Human Cancers: Selection versus Mutagenesis -- Lessons on p53 from Mouse Models -- TP63, TP73: The Guardian’s Elder Brothers -- The Regulation of p53 Protein Function by Phosphorylation -- The p53-Mdm2 Loop: A Critical Juncture of Stress Response -- Cooperation between MDM2 and MDMX in the Regulation of p53 -- Regulation and Function of the Original p53- Inducible p21 Gene -- p53 Localization -- Modes of p53 Interactions with DNA in the Chromatin Context -- p53’s Dilemma in Transcription: Analysis by Microarrays -- Tumor Viruses and p53 -- p53 and Immunity.
En: Springer eBooksResumen: Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research.
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Existencias
Tipo de ítem Biblioteca actual Colección Signatura Copia número Estado Fecha de vencimiento Código de barras
Libro Electrónico Biblioteca Electrónica
Colección de Libros Electrónicos RC261 -271 (Browse shelf(Abre debajo)) 1 No para préstamo 372130-2001

TP53 Mutations in Human Cancers: Selection versus Mutagenesis -- Lessons on p53 from Mouse Models -- TP63, TP73: The Guardian’s Elder Brothers -- The Regulation of p53 Protein Function by Phosphorylation -- The p53-Mdm2 Loop: A Critical Juncture of Stress Response -- Cooperation between MDM2 and MDMX in the Regulation of p53 -- Regulation and Function of the Original p53- Inducible p21 Gene -- p53 Localization -- Modes of p53 Interactions with DNA in the Chromatin Context -- p53’s Dilemma in Transcription: Analysis by Microarrays -- Tumor Viruses and p53 -- p53 and Immunity.

Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research.

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