Weighted Network Analysis [recurso electrónico] : Applications in Genomics and Systems Biology / by Steve Horvath.
Tipo de material: TextoEditor: New York, NY : Springer New York : Imprint: Springer, 2011Descripción: XXIII, 421 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9781441988195Tema(s): Life sciences | Human genetics | Bioinformatics | Biological models | Biology -- Data processing | Life Sciences | Systems Biology | Bioinformatics | Human Genetics | Computer Appl. in Life SciencesFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 570 Clasificación LoC:QH301-705Recursos en línea: Libro electrónicoTipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
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Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | QH301 -705 (Browse shelf(Abre debajo)) | 1 | No para préstamo | 372186-2001 |
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QH301 -705 Bergey’s Manual of Systematic Bacteriology | QH301 -705 BetaSys | QH301 -705 Understanding the Dynamics of Biological Systems | QH301 -705 Weighted Network Analysis | QH301 -705 Nature at Work: Ongoing Saga of Evolution | QH301 -705 In vitro screening of plant resources for extra-nutritional attributes in ruminants: nuclear and related methodologies | QH301 -705 Biocommunication and Natural Genome Editing |
Preface -- Networks and fundamental concepts -- Approximately factorizable networks -- Different type of network concepts -- Adjacency functions and their topological effects -- Correlation and gene co-expression networks -- Geometric interpretation of correlation networks using the singular value decomposition -- Constructing networks from matrices -- Clustering Procedures and module detection -- Evaluating whether a module is preserved in another network -- Association and statistical significance measures -- Structural equation models and directed networks -- Integrated weighted correlation network analysis of mouse liver gene expression data -- Networks based on regression models and prediction methods -- Networks between categorical or discretized numeric variables -- Networks based on the joint probability distribution of random variables -- Index.
This book presents state-of-the-art methods, software and applications surrounding weighted networks. Most methods and results also apply to unweighted networks. Although aspects of weighted network analysis relate to standard data mining methods, the intuitive network language and analysis framework transcend any particular analysis method. Weighted networks give rise to data reduction methods, clustering procedures, visualization methods, data exploratory methods, and intuitive approaches for integrating disparate data sets. Weighted networks have been used to analyze a variety of high dimensional genomic data sets including gene expression-, epigenetic-, methylation-, proteomics-, and fMRI- data. Chapters explore the fascinating topological structure of weighted networks and provide geometric interpretations of network methods. Powerful systems-level analysis methods result from combining network- with data mining methods. The book not only describes the WGCNA R package but also other software packages. Weighted gene co-expression network applications, real data sets, and exercises guide the reader on how to use these methods in practice, e.g. in systems-biologic or systems-genetic applications. The material is self-contained and only requires a minimum knowledge of statistics. The book is intended for students, faculty, and data analysts in many fields including bioinformatics, computational biology, statistics, computer science, biology, genetics, applied mathematics, physics, and social science.
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