IGFs:Local Repair and Survival Factors Throughout Life Span [recurso electrónico] / edited by David Clemmons, Iain C.A.F. Robinson, Yves Christen.

Por: Clemmons, David [editor.]Colaborador(es): Robinson, Iain C.A.F [editor.] | Christen, Yves [editor.] | SpringerLink (Online service)Tipo de material: TextoTextoSeries Research and Perspectives in Endocrine InteractionsEditor: Berlin, Heidelberg : Springer Berlin Heidelberg, 2010Descripción: online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783642043024Tema(s): Medicine | Medical genetics | Human physiology | Endocrinology | Medicine & Public Health | Endocrinology | Human Physiology | Gene FunctionFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 616.4 Clasificación LoC:RC648-665.2Recursos en línea: Libro electrónicoTexto
Contenidos:
GH & IGF1: Aspects of Global and Local Release and Actions -- Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation -- IGFBP2 Supports ex vivo Expansion of Hematopoietic Stem Cells -- The Role of Insulin-like Growth Factor-I in Central Nervous System Development -- Stimulation of Proliferative Pathways by IGF-binding Proteins -- Signaling Pathways that Regulate C. elegans Life Span -- IGF-1 Regulation of Skeletal Muscle Hypertrophy and Atrophy -- Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer -- The Functions of Insulin-like Peptides in Insects -- IGF Receptors in the Adult Brain -- The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span.
En: Springer eBooksResumen: Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.
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Tipo de ítem Biblioteca actual Colección Signatura Copia número Estado Fecha de vencimiento Código de barras
Libro Electrónico Biblioteca Electrónica
Colección de Libros Electrónicos RC648 -665.2 (Browse shelf(Abre debajo)) 1 No para préstamo 373635-2001

GH & IGF1: Aspects of Global and Local Release and Actions -- Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation -- IGFBP2 Supports ex vivo Expansion of Hematopoietic Stem Cells -- The Role of Insulin-like Growth Factor-I in Central Nervous System Development -- Stimulation of Proliferative Pathways by IGF-binding Proteins -- Signaling Pathways that Regulate C. elegans Life Span -- IGF-1 Regulation of Skeletal Muscle Hypertrophy and Atrophy -- Growth Hormone, Insulin-like Growth Factor I and Insulin: their Relationship to Aging and Cancer -- The Functions of Insulin-like Peptides in Insects -- IGF Receptors in the Adult Brain -- The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span.

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

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