Extracellular Matrix Degradation [recurso electrónico] / edited by William C. Parks, Robert P. Mecham.
Tipo de material: TextoSeries Biology of Extracellular Matrix ; 2Editor: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011Descripción: X, 255 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783642168611Tema(s): Life sciences | Medicine | Biochemistry | Cytology | Life Sciences | Cell Biology | Biochemistry, general | Protein Science | Molecular MedicineFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 571.6 Clasificación LoC:QH573-671Recursos en línea: Libro electrónicoTipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
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Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | QH573 -671 (Browse shelf(Abre debajo)) | 1 | No para préstamo | 375414-2001 |
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QH573 -671 Sensory and Metabolic Control of Energy Balance | QH573 -671 The Extracellular Matrix: an Overview | QH573 -671 Glycans in Diseases and Therapeutics | QH573 -671 Extracellular Matrix Degradation | QH573 -671 Mechanosensing Biology | QH573 -671 Mechanosensitivity and Mechanotransduction | QH573 -671 Intracellular Delivery |
Matrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix -- Role of Cysteine Cathepsins in Extracellular Proteolysis -- Cooperation between proteolysis and endocytosis in collagen turnover -- Pericellular Proteolysis -- Triple Helicase Activity and the Structural Basis of Collagenolysis -- Structural Basis of Extracellular Matrix Interactions with Matrix Metalloproteinases -- The Role of Matrix Metalloproteinases in Cellular Invasion and Metastasis -- Degradation of bone and the role of osteoclasts, bone lining cells and osteocytes -- Consequences of Elastolysis.
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
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