Targeting Functional Centers of the Ribosome [recurso electrónico] / by Chen Davidovich.
Tipo de material: TextoSeries Springer ThesesEditor: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011Descripción: XIV, 74 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783642169311Tema(s): Life sciences | Chemistry, Organic | Nucleic acids | Biochemistry | Life Sciences | Nucleic Acid Chemistry | Protein Science | Organic ChemistryFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 572.84 Clasificación LoC:QD433-436Recursos en línea: Libro electrónicoTipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
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Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | QD433 -436 (Browse shelf(Abre debajo)) | 1 | No para préstamo | 375427-2001 |
Introduction -- Methods -- Results -- Discussion.
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
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