Between the lines of genetic code [recurso electrónico] : genetic interactions in understanding disease and complex phenotypes / edited by Leonid Padyukov.
Tipo de material:
TextoDetalles de publicación: Amsterdam : Elsevier/AP, c2014Descripción: 1 online resource (xxi, 203 p.) : illTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 1299964729 (electronic bk.); 9781299964723 (electronic bk.); 0123973023 (electronic bk.); 9780123973023 (electronic bk.)Tema(s): Genotype-environment interaction | Phenotype | Genetics -- Methodology | Genetic disorders | Genetic disorders | Genetics -- Methodology | Genotype-environment interaction | Phenotype | Genetics, Medical | Gene-Environment Interaction | Genetic ResearchGénero/Forma: Electronic books.Formatos físicos adicionales: Print version:: Between the lines of genetic code.Clasificación CDD: 572.8 Clasificación LoC:RB155Recursos en línea: Libro electrónico ScienceDirect
Resumen: Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field. Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future.
| Tipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
|---|---|---|---|---|---|---|---|
| Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | RB155 (Browse shelf(Abre debajo)) | 1 | No para préstamo | 380199-2001 |
Description based on print version record.
Includes bibliographical references and index.
Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field. Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future.
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