Seldin and Giebisch's the kidney [recurso electrónico] : physiology and pathophysiology / [edited by] Robert J. Alpern, Orson W. Moe, Michael Caplan.

A classic nephrology reference for over 25 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch's The Kidney is your number one source for information. Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters.Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions.

Includes bibliographical references and index.

Epithelial Cell Structure and Polarity -- Mechanisms of Ion Transport across Cell Membranes -- Renal Ion-Translocating ATPases -- Mechanisms of Water Transport Across Cell Membranes and Epithelia -- Cell Volume Control -- Solute Transport, Energy Consumption, and Production in the Kidney -- Electrophysiological Analysis of Transepithelial Transport -- Renal Ion Channels, Electrophysiology of Transport, and Channelopathies -- Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular Walls -- External Balance of Electrolytes and Acids and Alkali -- Renal Cilia Structure, Function, and Physiology -- Intercellular Junctions -- Principles of Cell Signaling -- Scaffolding Proteins in Transport Regulation -- The Renin-Angiotensin System -- Neural Control of Renal Function -- Eicosanoids and Renal Function -- Extracellular Nucleotides and Renal Function -- Paracrine Regulation of Renal Function by Dopamine -- Structural Organization of the Mammalian Kidney -- Biophysical Basis of Glomerular Filtration -- Glomerular Cell Biology -- Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion -- Renal Cortical and Medullary Microcirculations: Structure and Function -- Molecular and Cellular Mechanisms of Kidney Development -- Molecular and Cellular Mechanisms of Glomerular Capillary Development -- Postnatal Renal Development -- Renal Hyperplasia and Hypertrophy -- Stem Cells and Generation of New Cells in the Adult Kidney -- Epithelial Na + Channels -- Anion Channels -- Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney -- Sodium and Chloride Transport: Proximal Nephron -- Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct -- Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron -- Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies -- Natriuretic Hormones -- Pathophysiology of Sodium Retention and Wastage -- Physiology and Pathophysiology of Hypertension -- Physiology and Pathophysiology of Diuretic Action -- Aquaporin Water Channels in Mammalian Kidney -- Thirst and Vasopressin -- The Urine Concentrating Mechanism and Urea Transporters -- Hyponatremia -- Hypernatremic States --

Polyuria and Diabetes Insipidus -- The Molecular Biology of Renal K + Channels -- Extrarenal Potassium Metabolism -- Regulation of K + Excretion -- Physiopathology of Potassium Deficiency -- Clinical Disorders of Hyperkalemia -- Control of Intracellular pH -- SLC₄ Sodium-Driven Bicarbonate Transporters -- The SLC₄ Anion Exchanger Gene Family -- Cellular Mechanisms of Renal Tubular Acidification -- Chemoreceptors, Breathing and pH -- Renal Ammonium Ion Production and Excretion -- Clinical Syndromes of Metabolic Alkalosis -- Clinical Syndromes of Metabolic Acidosis -- Respiratory Acid-Base Disorders -- Mechanisms and Disorders of Magnesium Metabolism -- Calcium Channels -- The Calcium-Sensing Receptor -- The Calcium-Sensing Receptor -- Renal Calcium Metabolism -- The Hormonal Regulation of Calcium Metabolism -- Disorders of Calcium Metabolism -- Pathogenesis and Treatment of Nephrolithiasis -- Proximal Tubular Handling of Phosphate -- Clinical Disturbances of Phosphate Homeostasis -- Glucose Reabsorption in The Kidney -- Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias -- Organic Anion and Cation Transporters in Renal Elimination of Drugs -- Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria -- Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders -- Biomarkers for Assessment of Renal Function During Acute Kidney Injury -- Pathophysiology of Acute Kidney Injury -- Ischemic Renal Disease -- Pathophysiology and Pathogenesis of Diabetic Nephropathy -- Renal Failure in Cirrhosis -- Autosomal Dominant Polycystic Kidney Disease -- Renal Physiology and Disease in Pregnancy -- Immune and Inflammatory Glomerular Diseases -- Immunologic Mechanisms of Vasculitis -- Genetic Abnormalities in Glomerular Function -- Cellular Mechanisms of Drug Nephrotoxicity -- Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease -- The Inflammatory Response to Ischemic Acute Renal Injury -- Catalytic (Labile) Iron in Kidney Disease -- Chronic Kidney Disease -- Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein -- Management of Calcium and Bone Disease in Renal Patients -- Hematopoiesis and the Kidney -- Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient -- Homeostasis of Solute and Water by the Transplanted Kidney -- Renal Disposition of Drugs and Translation to Dosing Strategies.

Description based on online resource; title from PDF title page (Ebrary, viewed Aug. 1, 2013).

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