Targeting Trafficking in Drug Development [electronic resource] / edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.

Colaborador(es): Ulloa-Aguirre, Alfredo [editor.] | Tao, Ya-Xiong [editor.] | SpringerLink (Online service)Tipo de material: TextoTextoSeries Handbook of Experimental Pharmacology ; 245Editor: Cham : Springer International Publishing : Imprint: Springer, 2018Edición: 1st ed. 2018Descripción: VIII, 425 p. 57 illus. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783319741642Tema(s): Pharmacology | Cell biology | Pharmacology/Toxicology | Cell BiologyFormatos físicos adicionales: Printed edition:: Sin título; Printed edition:: Sin título; Printed edition:: Sin títuloClasificación CDD: 615 Clasificación LoC:RM1-950Recursos en línea: Libro electrónicoTexto
Contenidos:
1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .
En: Springer Nature eBookResumen: Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

UABC ; Temporal ; 01/01/2021-12/31/2023.

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