Chemistry and Biology of O-GlcNAcylation [electronic resource] / edited by Wen Yi.

Colaborador(es): Yi, Wen [editor.] | SpringerLink (Online service)Tipo de material: TextoTextoEditor: Singapore : Springer Nature Singapore : Imprint: Springer, 2024Edición: 1st ed. 2024Descripción: VII, 178 p. 44 illus., 39 illus. in color. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9789819748648Tema(s): Medicine -- Research | Biology -- Research | Cytology | Biomedical Research | Cell BiologyFormatos físicos adicionales: Printed edition:: Sin título; Printed edition:: Sin título; Printed edition:: Sin títuloClasificación CDD: 610.72 Clasificación LoC:R850.A1-854QH315-320Recursos en línea: Libro electrónicoTexto
Contenidos:
Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation -- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry -- Chapter 3. O-GlcNAcylation and cell metabolism -- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics -- Chapter 5. O-GlcNAcylation and signal transduction -- Chapter 6. O-GlcNAcylation and stem cells -- Chapter 7. O-GlcNAcylation and immune regulation -- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.
En: Springer Nature eBookResumen: O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.
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Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation -- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry -- Chapter 3. O-GlcNAcylation and cell metabolism -- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics -- Chapter 5. O-GlcNAcylation and signal transduction -- Chapter 6. O-GlcNAcylation and stem cells -- Chapter 7. O-GlcNAcylation and immune regulation -- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.

O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.

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