TY  - BOOK
AU  - Wahnschaffe,U.
ED  - United Nations Environment Programme.
ED  - International Labour Organisation.
ED  - World Health Organization.
ED  - Inter-Organization Programme for the Sound Management of Chemicals.
ED  - International Program on Chemical Safety.
TI  - Transgenic animal mutagenicity assays
T2  - Environmental health criteria,
SN  - 9789241572330
AV  - RA1224.4.M86 T73 2006
PY  - 2006///
CY  - Geneva
PB  - World Health Organization
KW  - Prueba de la mutagenicidad
KW  - Mutagenicity Tests
KW  - Animales, geneticamente modificados
KW  - Animals, Genetically Modified
KW  - genetics
KW  - Mutagen
KW  - Toxicidad
KW  - Mutagens
KW  - toxicity
KW  - Gravamen de riesgo
KW  - Risk Assessment
KW  - Mutagenicity testing
KW  - Animales transgenicos
KW  - Transgenic animals
KW  - Toxicología genetica
KW  - Genetic toxicology
KW  - Gravamen de riego de salud
KW  - Health risk assessment
KW  - Mutagênese (testes)
KW  - larpcal
KW  - Camundongos (genética)
KW  - Medição de risco
KW  - Exposição ambiental
N1  - "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."; "International Programme on Chemical Safety"--Cover; Includes bibliographical references (p. 179-214); pt.1. Overview of genotoxicity testing and transgenic animal mutagenicity systems -- pt. 2. Comparison of the LACI model and the LACZ model with conventional test systems -- pt. 3. Applications of transgenic animal mutagenicity studies -- pt. 4. Evaluation, conclusions and recommendations
N2  - This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research.  Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays.  Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description
UR  - http://whqlibdoc.who.int/publications/2006/9241572337_eng.pdf
ER  -