TY - BOOK AU - Watts,Peter AU - Sheffer,Marla ED - United Nations Environment Programme. ED - International Labour Organisation. ED - Inter-Organization Programme for the Sound Management of Chemicals. ED - World Health Organization. TI - Tetrachloroethene T2 - Concise international chemical assessment document, SN - 9241530685 AV - RA1190 .C65 2006 PY - 2006/// CY - Geneva PB - World Health Organization KW - Tetrachloroethylene KW - adverse effects KW - Environmental Exposure KW - Risk Assessment KW - toxicity KW - Environmental aspects KW - Physiological effect KW - Solvents KW - Tetrachloorethyleen KW - gtt KW - Toxiciteit KW - Blootstelling KW - Gezondheidseffecten KW - Arbeidshygiëne KW - Veiligheid KW - Farmacologia KW - larpcal KW - Tétrachloroéthylène KW - Solvants KW - Aspect de l'environnement N1 - "Technically and linguistically edited by Marla Sheffer."--P. [ii]; "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."; Incluye referencias bibliográficas (p. 75-92); Identity and physical/chemical properties -- Analytical methods -- Sources of human and environmental exposure -- Environmental transport, distribution, and transformation -- Environmental levels and human exposure -- Comparative kinetics and metabolism in laboratory animals and humans -- Effects on laboratory mammals and in vitro test systems -- Effects on humans -- Effects on other organisms in the laboratory and field -- Effects evaluation -- Previous evaluations by IOMC bodies N2 - Tetrachloroethene is used mainly in the dry cleaning of textiles, as a chemical intermediate and in metal degreasing. This report evaluates the available scientific literature on the health and environmental effects of tetrachloroethene based on selected national and regional evaluations. Of key interest is the relevance of several types of tumors included by tetrachloroethene in rats and mice. The report goes on to establish the criteria for setting tolerable intakes and concentrations taking into consideration the potential carcinogenicity, neurotoxicity, kidney, liver and reproductive/developmental toxicity and cancer. Environmental effects are assessed for terrestrial and aquatic organisms , sediment-dwelling organisms and micro-organisms in sewerage treatment processes. In addition the risks of harm to plants from air emissions of tetrachloroethene are discussed. Uncertainties in the risk assessment are set out for both human health and the environment.--Publisher's decription UR - http://whqlibdoc.who.int/publications/2006/9241530685_eng.pdf ER -