TY  - BOOK
AU  - Booß-Bavnbek,Bernhelm
AU  - Klösgen,Beate
AU  - Larsen,Jesper
AU  - Pociot,Flemming
AU  - Renström,Erik
ED  - SpringerLink (Online service)
TI  - BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells 
T2  - Systems Biology
SN  - 9781441969569
AV  - QH301-705 
U1  - 570 23
PY  - 2011///
CY  - New York, NY
PB  - Springer New York
KW  - Life sciences
KW  - Human genetics
KW  - Diabetes
KW  - Bioinformatics
KW  - Biological models
KW  - Life Sciences
KW  - Systems Biology
KW  - Human Genetics
N1  - Preface -- Systems biology of ß-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in ß-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in ß-cells -- ß-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic ß-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic ß-cells -- Mapping the ß-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in ß-cell function -- Proteomic analysis of the pancreatic islet ß-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the ß-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in ß-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index
N2  - The insulin secreting ß-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the ??-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-6956-9
ER  -