TY  - BOOK
AU  - Fantus,I.George
ED  - SpringerLink (Online service)
TI  - Insulin Resistance and Cancer: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications 
T2  - Energy Balance and Cancer
SN  - 9781441999115
AV  - RC261-271 
U1  - 614.5999 23
PY  - 2011///
CY  - New York, NY
PB  - Springer New York
KW  - Medicine
KW  - Oncology
KW  - Toxicology
KW  - Biomedicine
KW  - Cancer Research
KW  - Pharmacology/Toxicology
N1  - Insulin and the Physiology of Carbohydrate and Lipid Metabolism -- Insulin Signalling: Cellular and Molecular Mechanisms -- Mechanisms of Insulin Resistance, Obesity and Metabolic Syndrome -- Obesity and Cancer: Epidemiology -- Insulin, Insulin Resistance and Cancer Associations -- Animal Models of Hyperinsulinemia, Insulin Resistance and Cancer -- Actions of Insulin as a Survival and Growth Factor: Akt/PKB, mTOR and MAPK Signaling -- Potential Mechanisms Linking Insulin to Cancer -- Insulin-like Growth Factors and Cancer -- Insulin, IGF Receptors and Cancer -- Clinical Implications for Cancer Treatment and Prevention
N2  - This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-9911-5
ER  -