TY  - BOOK
AU  - Dormitzer,Philip R.
AU  - Mandl,Christian W.
AU  - Rappuoli,Rino
ED  - SpringerLink (Online service)
TI  - Replicating Vaccines: A New Generation 
T2  - Birkhäuser Advances in Infectious Diseases
SN  - 9783034602778
AV  - QR46 
U1  - 616.9041 23
PY  - 2011///
CY  - Basel
PB  - Springer Basel
KW  - Medicine
KW  - Immunology
KW  - Microbiology
KW  - Vaccines
KW  - Medical virology
KW  - Biomedicine
KW  - Medical Microbiology
KW  - Vaccine
KW  - Virology
N1  - SECTION 1: Today’s Live Attenuated Vaccines -- Live Vaccines and their Role in Modern Vaccinology -- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster -- Classical Live Viral Vaccines -- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines -- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus -- Live Attenuated Shigella Vaccines. Is encouraging good enough? -- New generation BCG vaccines -- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines -- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines -- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches -- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread -- RSV Deletion Mutant – Innate Immunity -- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity -- SECTION 4: New Types of Replicating Vaccines -- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors -- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines -- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines -- Alphavirus Particle-based Vaccine Vectors -- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses
N2  - Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-0346-0277-8
ER  -