TY  - BOOK
AU  - Martens,Uwe M.
ED  - SpringerLink (Online service)
TI  - Small Molecules in Oncology
T2  - Recent Results in Cancer Research,
SN  - 9783642012228
AV  - RC254-282 
U1  - 616.994 23
PY  - 2010///
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg
KW  - Medicine
KW  - Oncology
KW  - Hematology
KW  - Medicine & Public Health
KW  - Cancer Research
N1  - Protein kinase inhibitors -- Imatinib Mesylate -- Erlotinib -- Axitinib (AG-013736) -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Epigenetic modifiers -- Decitabine -- 5-Azacytidine/Azacitidine -- Cell cycle inhibitors -- Bortezomib -- Temsirolimus -- Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor -- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1) -- Other novel agents -- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy -- GDC-0449 - Targeting the Hedgehog Signaling Pathway
N2  - Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-01222-8
ER  -