TY  - BOOK
AU  - Fromm,Martin F.
AU  - Kim,Richard B.
ED  - SpringerLink (Online service)
TI  - Drug Transporters
T2  - Handbook of Experimental Pharmacology,
SN  - 9783642145414
AV  - RM1-950 
U1  - 615 23
PY  - 2011///
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg
KW  - Medicine
KW  - Human physiology
KW  - Drug interactions
KW  - Toxicology
KW  - Pharmaceutical technology
KW  - Clinical medicine
KW  - Nephrology
KW  - Biomedicine
KW  - Pharmacology/Toxicology
KW  - Pharmaceutical Sciences/Technology
KW  - Human Physiology
KW  - Drug Resistance
KW  - Hepatology
N1  - From the contents -- Preface -- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport
N2  - It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-14541-4
ER  -