TY  - BOOK
AU  - Davidovich,Chen
ED  - SpringerLink (Online service)
TI  - Targeting Functional Centers of the Ribosome
T2  - Springer Theses
SN  - 9783642169311
AV  - QD433-436 
U1  - 572.84 23
PY  - 2011///
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg
KW  - Life sciences
KW  - Chemistry, Organic
KW  - Nucleic acids
KW  - Biochemistry
KW  - Life Sciences
KW  - Nucleic Acid Chemistry
KW  - Protein Science
KW  - Organic Chemistry
N1  - Introduction -- Methods -- Results -- Discussion
N2  - This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-16931-1
ER  -