TY  - BOOK
AU  - Prinz,Heino
ED  - SpringerLink (Online service)
TI  - Numerical Methods for the Life Scientist: Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB 
SN  - 9783642208201
AV  - QH324.2-324.25 
U1  - 570.285 23
PY  - 2011///
CY  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg, Imprint: Springer
KW  - Life sciences
KW  - Bioinformatics
KW  - Life Sciences
KW  - Computational Biology/Bioinformatics
KW  - Mathematical and Computational Biology
N1  - Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches.  
N2  - Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered
UR  - http://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-3-642-20820-1
ER  -