TY  - BOOK
AU  - Lai,Yurong
TI  - Transporters in drug discovery and development: detailed concepts and best practice 
T2  - Woodhead Publishing Series in Biomedicine
SN  - 9781908818287 (electronic bk.)
AV  - RM301.25 
U1  - 615.19 
PY  - 2013///
CY  - Oxford
PB  - Elsevier Science
KW  - Biopharmaceutics
KW  - Drug development
KW  - Drugs
KW  - Design
KW  - Drugs -- Design
KW  - MEDICAL / Pharmacology
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery; Includes bibliographical references and index; Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies
UR  - http://148.231.10.114:2048/login?url=http://www.sciencedirect.com/science/book/9781907568213
ER  -