TY  - BOOK
AU  - Kozlov,Andrei P.
TI  - Evolution by tumor neofunctionalization: the role of tumors in the origin of new cell types, tissues and organs 
SN  - 9780128004982
AV  - RD261 
U1  - 617.092 
PY  - 2014///
CY  - Burlington
PB  - Elsevier Science
KW  - Tumors
KW  - Molecular aspects
KW  - Evolution (Biology)
KW  - MEDICAL
KW  - Surgery
KW  - General
KW  - bisacsh
KW  - Electronic books
N1  - 1. The modern synthesis of evolutionary biology and the health sciences -- 2. Evolution and pathology -- 3. The widespread occurrences of tumors in multicellular organisms -- 4. Features of tumors that could be used in evolution -- 5. Tumors might participate in the evolution of ontogenesis -- 6. Tumors that might play a role in evolution -- 7. Tumors that have played a role in evolution -- 8. The general principles and molecular mechanism in the orgin of novel genes -- 9. The origin of evolutionary novel genes and the evolution of new functions and structural complexity of multicellular organisms -- 10. The orgin of new cell types, tissues and organs by tumor neofunctionalization -- 11. Experimental confirmation of nontrivial predictions of evolution by the tumor neofunctionalization hypothesis -- 12. Other evidence supporting the positive evolutionary role of tumors and the hypothesis of evolution by tumor neofunctionalization
N2  - Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution
UR  - http://148.231.10.114:2048/login?url=http://www.sciencedirect.com/science/book/9780128001653
ER  -