TY  - BOOK
AU  - Ciarimboli,Giuliano
AU  - Gautron,Sophie
AU  - Schlatter,Eberhard
ED  - SpringerLink (Online service)
TI  - Organic Cation Transporters: Integration of Physiology, Pathology, and Pharmacology 
SN  - 9783319237930
AV  - QP34-38 
U1  - 612 23
PY  - 2016///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Medicine
KW  - Human physiology
KW  - Pharmacology
KW  - Pathology
KW  - Biomedicine
KW  - Human Physiology
KW  - Pharmacology/Toxicology
N1  - Introduction to the cellular transport of organic cations -- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism -- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity -- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy -- Physiological and pathological regulation of transporters for organic cations -- Endocrine and metabolic regulation of transporters for organic cations -- Organic cation transporters (OCTs) as modulators of behavior and mood -- Organic cation transporters as modulators of neurodegeneration and neuroprotection -- Translational relevance of animal models for the study of organic cation transporter function -- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues
N2  - This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues.  This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists
UR  - http://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-23793-0
ER  -