TY  - BOOK
AU  - Frega,Monica
ED  - SpringerLink (Online service)
TI  - Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems
T2  - Springer Theses, Recognizing Outstanding Ph.D. Research,
SN  - 9783319302379
AV  - R856-857 
U1  - 610.28 23
PY  - 2016///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Engineering
KW  - Neurosciences
KW  - Cell physiology
KW  - Electronics
KW  - Microelectronics
KW  - Biomedical engineering
KW  - Biomedical Engineering
KW  - Cell Physiology
KW  - Electronics and Microelectronics, Instrumentation
N1  - Introduction -- Dissociated Neuronal Networks Coupled to Micro-Electrode Arrays Devices -- In Vitro Neuronal Networks -- 3D Neuronal Networks: State of the Art -- 3D Neuronal Networks Coupled to MEAs -- Neuro-pharmacological Studies -- Discussion and Conclusion -- Data Analysis
N2  - The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems. <
UR  - http://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-30237-9
ER  -