TY  - BOOK
AU  - Donnadieu,Emmanuel
ED  - SpringerLink (Online service)
TI  - Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
T2  - Resistance to Targeted Anti-Cancer Therapeutics,
SN  - 9783319422237
AV  - RC261-271 
U1  - 614.5999 23
PY  - 2016///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Medicine
KW  - Cancer research
KW  - Immunology
KW  - Molecular biology
KW  - Biomedicine
KW  - Cancer Research
KW  - Molecular Medicine
N1  - Introduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors
N2  - This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy
UR  - http://148.231.10.114:2048/login?url=http://dx.doi.org/10.1007/978-3-319-42223-7
ER  -