TY  - BOOK
AU  - Djouder,Nabil
ED  - SpringerLink (Online service)
TI  - Prefoldins: the new chaperones
T2  - Advances in Experimental Medicine and Biology,
SN  - 9783030007379
AV  - RB155-155.8 
U1  - 611.01816 23
PY  - 2018///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Human genetics
KW  - Molecular biology
KW  - Cell biology
KW  - Cancer research
KW  - Proteins 
KW  - Human Genetics
KW  - Molecular Medicine
KW  - Cell Biology
KW  - Cancer Research
KW  - Protein Science
KW  - Protein Structure
N1  - Acceso multiusuario; Preface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index
N2  - This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world
UR  - http://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-030-00737-9
ER  -