TY - BOOK AU - Jordan,Peter ED - SpringerLink (Online service) TI - Targeted Therapy of Colorectal Cancer Subtypes T2 - Advances in Experimental Medicine and Biology, SN - 9783030027711 AV - RC261-271 U1 - 614.5999 23 PY - 2018/// CY - Cham PB - Springer International Publishing, Imprint: Springer KW - Cancer research KW - Human genetics KW - Molecular biology KW - Biomedical engineering KW - Immunology KW - Cancer Research KW - Human Genetics KW - Molecular Medicine KW - Biomedical Engineering/Biotechnology N1 - Acceso multiusuario; Preface -- Colorectal Cancer Subtypes- the current portrait -- Targeting colon cancers with mutated BRAF and microsatellite instability -- Targeting KRAS mutant CMS3 subtype by metabolic inhibitors -- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer -- Targeting PTEN in colorectal cancers -- Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment?- Impact of the microenvironment on tumour budding in colorectal cancer -- Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all -- miRNAs as modulators of EGFR therapy in colorectal cancer -- Index N2 - In this book, a group of researchers shares their expertise on the identification and characterization of genetic colorectal cancer subtypes. They describe solid pathobiological knowledge on the distinct sporadic tumour subtypes, including the mutations found in oncogenes and tumour suppressor genes, the types of genomic instability encountered, and the cellular signalling pathways activated. The book content indicates opportunities for the development of further pathway-specific therapeutic drugs or drug combinations, allowing to cope with the appearance of resistant tumours. The nine chapters of this book cover the main aspects underlying colorectal cancer development but also of its therapeutic options, which have been undergoing substantial changes by moving from the use of general cytotoxic agents that affect rapidly growing cells to more tumour-specific drugs. In the first case, all dividing cells in the patient's body are affected and this causes severe and debilitating side effects. In the second case, the increasing knowledge about the molecular genetics of tumours has led to a new generation of drugs, which specifically interfere with the cell survival pathways that are activated in a given tumour. This allowed to identify groups of patients for targeted therapy that is much better tolerated. The book is thus an interesting update for health professionals on the current knowledge on heterogeneity in colorectal cancer. In addition, it should inspire the drug-developing scientific community by highlighting potential therapeutic Achilles heels of distinct subtypes of colorectal cancer UR - http://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-030-02771-1 ER -