TY  - BOOK
AU  - Bassaganya-Riera,Josep
ED  - SpringerLink (Online service)
TI  - Accelerated Path to Cures
SN  - 9783319732381
AV  - QR180-189.5 
U1  - 616.079 23
PY  - 2018///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Immunology
KW  - Bioinformatics
KW  - Health informatics
KW  - Bioinformatics 
KW  - Computational biology 
KW  - Computational Biology/Bioinformatics
KW  - Health Informatics
KW  - Computer Appl. in Life Sciences
N1  - Acceso multiusuario; Chapter 1: Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease -- Chapter 2: Computer-Aided Drug Discovery -- Chapter 3: Preclinical Studies: Efficacy and Safety -- Chapter 4: From Nutritional Immunology to Drug Development -- Chapter 5: Development of Synthetic Patient Populations and In Silico Clinical Trials
N2  - Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures. 
UR  - http://148.231.10.114:2048/login?url=https://doi.org/10.1007/978-3-319-73238-1
ER  -