Seeking Molecular Biomarkers for Schizophrenia Using ROC Analysis [electronic resource] / by Margareth Borges Coutinho Gallo.

Por: Borges Coutinho Gallo, Margareth [author.]Colaborador(es): SpringerLink (Online service)Tipo de material: Texto

TextoEditor: Cham : Springer Nature Switzerland : Imprint: Springer, 2024Edición: 1st ed. 2024Descripción: XV, 250 p. 96 illus., 95 illus. in color. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783031590283Tema(s): Bioinformatics | Medicine -- Research | Biology -- Research | Psychiatry | Computational and Systems Biology | Biomedical Research | PsychiatryFormatos físicos adicionales: Printed edition:: Sin título; Printed edition:: Sin título; Printed edition:: Sin títuloClasificación CDD: 570.285 | 570.113 Clasificación LoC:QH324.2-324.25Recursos en línea: Libro electrónico Texto

Contenidos:

Preface -- Hypotheses of the Pathophysiology of Schizophrenia Spectrum Disorders -- Biomarkers -- Biomarkers Related to the Hypotheses of the Pathophysiology of SSD -- Immunoinflammatory and Oxidative-Stress Related Biomarkers -- Gut Microbiota-Brain Axis and Related Biomarkers -- Neuroendocrine Biomarkers -- Neurotrophic Biomarkers -- Neurotransmitter Biomarkers -- Conclusions -- Step-by-Step Guide to Building a Diagnostic Model Using MetaboAnalyst -- Index.

En: Springer Nature eBookResumen: Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases.

Existencias ( 1 )
Notas de título ( 3 )

Existencias
Tipo de ítem	Biblioteca actual	Colección	Signatura	Copia número	Estado	Fecha de vencimiento	Código de barras
Libro Electrónico	Biblioteca Electrónica	Colección de Libros Electrónicos		1	No para préstamo

Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases.

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