NF-kB in Health and Disease [recurso electrónico] / edited by Michael Karin.

Por: Karin, Michael [editor.]Colaborador(es): SpringerLink (Online service)Tipo de material: TextoTextoSeries Current Topics in Microbiology and Immunology ; 349Editor: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011Descripción: VIII, 268 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9783642160172Tema(s): Medicine | Oncology | Biomedicine | Cancer ResearchFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 614.5999 Clasificación LoC:RC261-271Recursos en línea: Libro electrónicoTexto
Contenidos:
Preface -- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms -- IKK regulation and human genetics -- Specialized chromatin patterns in the control of inflammatory gene expression -- Macrophages and NF-kappaB in Cancer -- NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster -- IKK and NF-kappaB mediated functions in carcinogenesis -- Control of NF-kappaB activity by proteolysis -- NF-kappaB as a target for oncogenic viruses -- NF-kappaB and Innate Immunity -- Inhibition of NF-kappaB signaling as a strategy in disease therapy -- NF-?B and mucosal homeostasis -- NF-kappaB In liver cancer – the plot thickens -- Subject index.
En: Springer eBooksResumen: This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.
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Tipo de ítem Biblioteca actual Colección Signatura Copia número Estado Fecha de vencimiento Código de barras
Libro Electrónico Biblioteca Electrónica
Colección de Libros Electrónicos RC261 -271 (Browse shelf(Abre debajo)) 1 No para préstamo 375198-2001

Preface -- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms -- IKK regulation and human genetics -- Specialized chromatin patterns in the control of inflammatory gene expression -- Macrophages and NF-kappaB in Cancer -- NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster -- IKK and NF-kappaB mediated functions in carcinogenesis -- Control of NF-kappaB activity by proteolysis -- NF-kappaB as a target for oncogenic viruses -- NF-kappaB and Innate Immunity -- Inhibition of NF-kappaB signaling as a strategy in disease therapy -- NF-?B and mucosal homeostasis -- NF-kappaB In liver cancer – the plot thickens -- Subject index.

This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.

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