BetaSys [recurso electrónico] : Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells / edited by Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström.
Tipo de material: TextoSeries Systems Biology ; 2Editor: New York, NY : Springer New York, 2011Edición: 1Descripción: XX, 556 p. online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9781441969569Tema(s): Life sciences | Human genetics | Diabetes | Bioinformatics | Biological models | Life Sciences | Systems Biology | Human Genetics | Bioinformatics | DiabetesFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 570 Clasificación LoC:QH301-705Recursos en línea: Libro electrónicoTipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
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Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | QH301 -705 (Browse shelf(Abre debajo)) | 1 | No para préstamo | 371788-2001 |
Preface -- Systems biology of ß-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in ß-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in ß-cells -- ß-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic ß-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic ß-cells -- Mapping the ß-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in ß-cell function -- Proteomic analysis of the pancreatic islet ß-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the ß-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in ß-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index.
The insulin secreting ß-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the ??-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.
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