SuperMEN1 [recurso electrónico] : Pituitary, Parathyroid and Pancreas / edited by Katalin Balogh, Attila Patocs.

Por: Balogh, Katalin [editor.]Colaborador(es): Patocs, Attila [editor.] | SpringerLink (Online service)Tipo de material: TextoTextoSeries Advances in Experimental Medicine and Biology ; 668Editor: New York, NY : Springer New York, 2010Descripción: online resourceTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9781441916648Tema(s): Medicine | Biomedicine | Biomedicine generalFormatos físicos adicionales: Printed edition:: Sin títuloClasificación CDD: 610 Clasificación LoC:R-RZRecursos en línea: Libro electrónicoTexto
Contenidos:
MEN1 Clinical Background -- Genetic Background of MEN1: From Genetic Homogeneity to Functional Diversity -- Menin: The Protein Behind the MEN1 Syndrome -- Cellular Functions of Menin -- The Role of Menin in Hematopoiesis -- Role of Menin in Bone Development -- Activin, TGF-? and Menin in Pituitary Tumorigenesis -- The Role of Menin in Parathyroid Tumorigenesis -- Role of Menin in Neuroendocrine Tumorigenesis -- Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis -- Functional Studies of Menin through Genetic Manipulation of the Men1 Homolog in Mice.
En: Springer eBooksResumen: The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .
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Existencias
Tipo de ítem Biblioteca actual Colección Signatura Copia número Estado Fecha de vencimiento Código de barras
Libro Electrónico Biblioteca Electrónica
Colección de Libros Electrónicos R -RZ (Browse shelf(Abre debajo)) 1 No para préstamo 371405-2001

MEN1 Clinical Background -- Genetic Background of MEN1: From Genetic Homogeneity to Functional Diversity -- Menin: The Protein Behind the MEN1 Syndrome -- Cellular Functions of Menin -- The Role of Menin in Hematopoiesis -- Role of Menin in Bone Development -- Activin, TGF-? and Menin in Pituitary Tumorigenesis -- The Role of Menin in Parathyroid Tumorigenesis -- Role of Menin in Neuroendocrine Tumorigenesis -- Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis -- Functional Studies of Menin through Genetic Manipulation of the Men1 Homolog in Mice.

The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .

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