Protein bioinformatics [recurso electrónico] : from sequence to function / M. Michael Gromiha.
Tipo de material: TextoDetalles de publicación: Amsterdam ; Boston : Academic Press/Elsevier, 2010Descripción: 1 online resource (xix, 320 pages, [8] pages of plates) : illustrations (some color)Tipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9780123884244 (electronic bk.); 0123884241 (electronic bk.)Tema(s): Proteins -- Structure -- Data processing | Proteins -- Metabolism -- Data processing | Bioinformatics | SCIENCE -- Life Sciences -- Biochemistry | Biochemie | Bioinformatik | Protein-Protein-Wechselwirkung | Proteine | Proteinfaltung | Strukturaufklärung | Biochemie | Bioinformatik | Protein-Protein-Wechselwirkung | Proteine | Proteinfaltung | Strukturaufklärung | Sequence Analysis, Protein | Protein Conformation | Computational Biology -- methodsGénero/Forma: Electronic books.Formatos físicos adicionales: Print version:: Protein bioinformatics.Clasificación CDD: 572.60285 Clasificación LoC:QP551 | .G76 2010ebRecursos en línea: Libro electrónico ScienceDirectTipo de ítem | Biblioteca actual | Colección | Signatura | Copia número | Estado | Fecha de vencimiento | Código de barras |
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Libro Electrónico | Biblioteca Electrónica | Colección de Libros Electrónicos | QP551 .G76 2010 EB (Browse shelf(Abre debajo)) | 1 | No para préstamo | 380692-2001 |
Includes bibliographical references and index.
One of the most pressing tasks in biotechnology today is to unlock the function of each of the thousands of new genes identified every day. Scientists do this by analyzing and interpreting proteins, which are considered the task force of a gene. This single source reference covers all aspects of proteins, explaining fundamentals, synthesizing the latest literature, and demonstrating the most important bioinformatics tools available today for protein analysis, interpretation and prediction. Students and researchers of biotechnology, bioinformatics, proteomics, protein engineering, biophysics, c.
1 Proteins 1.1 Building blocks 1.2 Hierarchical representation of proteins 1.3 Structural classification of proteins 1.4 Databases for protein sequences 1.5 Exercises 1.6 References 2. Protein Sequence Analysis 2.1 Sequence alignment 2.2 Programs for aligning protein sequences 2.3 Amino acid properties 2.4 Amphipathic character of a-helices and b-strands 2.5 Online tools for sequence analysis 2.6 Exercises 2.7 References 3 Protein Structure Analysis 3.1 Assignment of secondary structures 3.2 Computation of solvent accessibility 3.3 Representation of solvent accessibility 3.4 Residue-residue contacts 3.5 Amino acid clusters in protein structures 3.6 Contact potentials 3.7 Cation--p interactions in protein structures 3.8 Non canonical interactions 3.9 Free energy calculations 3.10 Amino acid properties derived from protein structural data 3.11 Parameters for proteins 3.12 Exercises 3.13 References 4. Protein Folding Kinetics 4.1 F value analysis 4.2 Experimental studies 4.3 Relationship between amino acid properties and F values 4.4 Hydrophobic clusters and long-range contact network in F value analysis 4.5 Kinetic database for proteins 4.6 Prediction of protein folding rates 4.7 Relationship between F values and folding rates 4.8 References 5. Protein Structure Prediction 5.1 Secondary structure 5.2 Protein structural class 5.3 Secondary structure content 5.4 Discrimination of transmembrane helical proteins and predicting their membrane spanning segments 5.5 Discrimination of transmembrane strand proteins 5.6 Identification of membrane spanning b -strand segments 5.7 Solvent accessibility 5.8 Inter-residue contact prediction 5.9 Protein tertiary structure prediction 5.10 Webservers for protein structure prediction 5.11 Exercises 5.12 References 6 Protein Stability 6.1 Determination of protein stability 6.2 Thermodynamic database for proteins and mutants 6.3 Relative contribution of non-covalent interactions to protein stability 6.4 Stability of thermophilic proteins 6.5 Analysis and Prediction of protein mutant stability 6.6 Exercises 6.7 References 7 Protein Interactions 7.1 Protein-protein interactions 7.2 Protein-DNA interactions 7.3 Protein-RNA interactions 7.4 Protein-ligand interactions 7.5 Exercises 7.6 References Appendix A List of protein databases/webservers.
Print version record.
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