Therapeutic applications of quadruplex nucleic acids [recurso electrónico] / Stephen Neidle.

Por: Neidle, StephenTipo de material: TextoTextoDetalles de publicación: London ; Waltham, MA : Elsevier/Academic Press, 2012Edición: 1st edDescripción: 1 online resource (xii, 196 pages) : illustrationsTipo de contenido: text Tipo de medio: computer Tipo de portador: online resourceISBN: 9780123751386 (electronic bk.); 0123751381 (electronic bk.); 9780123751393 (electronic bk.); 012375139X (electronic bk.)Tema(s): Quadruplex nucleic acids -- Therapeutic use | G-Quadruplexes | Antineoplastic Agents -- therapeutic use | Antineoplastic Agents -- pharmacology | Neoplasms -- drug therapy | Nucleic Acid Conformation | Telomere -- chemistry | MEDICAL -- PharmacologyGénero/Forma: Electronic books.Formatos físicos adicionales: Print version:: Therapeutic applications of quadruplex nucleic acids.Clasificación CDD: 615.36 Clasificación LoC:QP625.Q33 | N45 2012Recursos en línea: Libro electrónico ScienceDirectTexto
Contenidos:
Intro -- history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes -- involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease -- applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands -- chemistry and design -- selectivity and assays -- Quadruplex ligands -- basic biology and assays indirect and direct -- Quadruplex ligands -- pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs -- therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions.
Resumen: New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research.
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Libro Electrónico Biblioteca Electrónica
Colección de Libros Electrónicos QP625 .Q33 N45 2012 (Browse shelf(Abre debajo)) 1 No para préstamo 380654-2001

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research.

Intro -- history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes -- involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease -- applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands -- chemistry and design -- selectivity and assays -- Quadruplex ligands -- basic biology and assays indirect and direct -- Quadruplex ligands -- pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs -- therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions.

Includes bibliographical references and index.

Description based on print version record.

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