Principles of tissue engineering [recurso electrónico] / edited by Robert Lanza, Robert Langer, Joseph Vacanti.

Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies -such as brain-machine interfaces for controlling bionics and neuroprostheses- is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production.

Includes bibliographical references and index.

Introduction to tissue engineering. The history and scope of tissue engineering -- The challenge of imitating nature -- Moving into the clinic -- Future perspectives -- The basis of growth and differentiation. Molecular biology of the cell -- Organization of cells into higher-ordered structures -- Dynamics of cell-ECM interactions -- Matrix molecules and their ligands -- Morphogenesis and tissue engineering -- Gene expression, cell determination and differentiation -- In vitro control of tissue development. Engineering functional tissues -- Principles of tissue culture and bioreactor design -- Regulation of cell behavior by extracellular proteins -- Growth factors -- Mechanochemical control of cell fate switching -- In vivo synthesis of tissues and organs. In vivo synthesis of tissues and organs -- Models as precursors for prosthetic devices -- Quantitative aspects -- Biomaterials in tissue engineering. Micro-scale patterning of cells and their environment -- Cell interactions with polymers -- Matrix effects -- Polymer scaffold fabrication -- Biodegradable polymers -- Micro- and nanofabricated scaffolds -- Three-dimensional scaffolds -- Tissue engineering and transplantation in the fetus -- Immunomodulation -- Immunoisolation -- Engineering challenges in immunobarrier device development -- Embryonic stem cells -- Adult epithelial tissue stem cells -- Embryonic stem cells as a cell source for tissue engineering -- Postnatal stem cells -- Gene therapy. Gene therapy -- Gene delivery into cells and tissues -- Breast reconstruction -- Cardiovascular system. Progenitor cells and cardiac homeostasis -- Cardiac-tissue engineering -- Blood vessels -- Heart valves -- Generation of islets from stem cells -- Bioartificial pancreas -- Engineering pancreatic beta-cells -- Thymus and parathyroid organogenesis -- Gastrointestinal system. Adult stem cells in normal gastrointestinal function and inflammatory disease -- Alimentary tract -- Liver stem cells -- Liver -- Hematopoietic system. Hematopoietic stem cells -- Red blood cell substitutes -- Lymphoid cells -- Kidney and genitourinary system. Stem cells in kidney development and regeneration -- Renal replacement devices -- Genitourinary system -- Musculoskeletal system. Mesenchymal stem cells -- Bone regeneration -- Bone and cartilage reconstruction -- Regeneration and replacement of the intervertebral disc -- Articular cartilage injury -- Tendons and ligaments -- Mechanosensory mechanisms in bone -- Skeletal-tissue engineering -- Neural stem cells -- Brain implants -- Spinal cord injury -- Protection and repair of audition -- Ophthalmic applications. Stem cells in the eye -- Corneal-tissue replacement -- Vision enhancement systems -- Biological tooth replacement and repair -- Oral and maxillofacial surgery -- Periodontal-tissue engineering -- Progenitor cells in the respiratory system -- Lungs -- Cutaneous stem cells -- Wound repair -- Bioengineered skin constructs -- Current state of clinical application -- Tissue-engineered skin products -- Tissue-engineered cartilage products -- Tissue-engineered bone products -- Tissue-engineered cardiovascular products -- Tissue-engineered organs -- Regulation and ethics. The tissue-engineering industry -- The regulatory path from concept to market -- Epilogue.

Description based on online resource; title from resource home page (ebrary, viewed on January 20, 2015).

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