000			03081cam a2200301 a 4500
001			u317915
003			SIRSI
005			20160811212106.0
008			081027s2009 sz ad fr 000 0 eng d
020			_a9789241572392
020			_a9241572396
040			_cMX-MeUAM
050		0	_aRM301.8 _bP75 2009
245	0	0	_aPrinciples for modelling dose-response for the risk assessment of chemicals / _cfirst draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals.
260			_aGeneva, Switzerland : _bWorld Health Organization, _cc2009.
300			_axx, 137 p. : _bil., gráficos ; _c21 cm.
490	1		_aEnvironmental health criteria, _x0250-863X ; _v239
520	3		_aThis volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.
505	2		_aSummary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations.
500			_a"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
504			_aIncluye referencias bibliográficas (p. 103-110).
650		7	_aDrogas _xRelación-dosis-respuesta. _2lemb
710	2		_aWorld Health Organization.
830		0	_aEnvironmental health criteria ; _v239.
596			_a4 12
942			_cLIBRO
999			_c159632 _d159632