000			02725nam a22004455i 4500
001			u371255
003			SIRSI
005			20160812080118.0
007			cr nn 008mamaa
008			100301s2010 xxu| s |||| 0|eng d
020			_a9781441911117 _9978-1-4419-1111-7
040			_cMX-MeUAM
050		4	_aRC261-271
082	0	4	_a614.5999 _223
100	1		_aGolen, Kenneth. _eeditor.
245	1	4	_aThe Rho GTPases in Cancer _h[recurso electrónico] / _cedited by Kenneth Golen.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXXII, 206 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aAn Overview of the Rho GTPases -- Overview of Rho GTPase History -- Rho Proteins in Cancer -- The Rho Regulatory Proteins in Cancer -- RhoGDIs in Cancer -- Signaling through Galpha12/13 and RGS-RhoGEFs -- Vav Proteins in Cancer -- Rho GTPase-Activating Proteins in Cancer -- The Rho GTPase Proteins and Cancer -- RhoBTB Proteins in Cancer -- RhoC GTPase in Cancer Progression and Metastasis -- RhoB GTPase and FTIs in Cancer -- Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview -- The Rho-Regulated ROCK Kinases in Cancer.
520			_aThe Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aPharmacology/Toxicology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441911100
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-1111-7
596			_a19
942			_cLIBRO_ELEC
999			_c199135 _d199135