000			04452nam a22004935i 4500
001			u371268
003			SIRSI
005			20160812080119.0
007			cr nn 008mamaa
008			100301s2010 xxu| s |||| 0|eng d
020			_a9781441911704 _9978-1-4419-1170-4
040			_cMX-MeUAM
050		4	_aRC321-580
082	0	4	_a612.8 _223
100	1		_aBerezin, Vladimir. _eeditor.
245	1	0	_aStructure and Function of the Neural Cell Adhesion Molecule NCAM _h[recurso electrónico] / _cedited by Vladimir Berezin.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXVI, 434p. 67 illus., 45 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v663
505	0		_aStructure and Ligands of NCAM -- Structural Biology of NCAM -- Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses -- Intracelluar Ligands of NCAM -- NCAM and the FGF-Receptor -- The Role of ATP in the Regulation of NCAM Function -- NCAM and Polysialic Acid -- Polysialylation of NCAM -- Structural Basis for the Polysialylation of the Neural Cell Adhesion Molecule -- The Role of PSA-NCAM in Adult Neurogenesis -- Use of PSA-NCAM in Repair of the Central Nervous System -- NCAM-mediated Signal Transduction -- Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth -- Role of the Growth-Associated Protein GAP-43 in NCAM-Mediated Neurite Outgrowth -- The Neural Cell Adhesion Molecule NCAM and Lipid Rafts -- The Neural Cell Adhesion Molecule and Epidermal Growth Factor Receptor: Signaling Crosstalk -- NCAM Metabolism -- Biosynthesis of NCAM -- Soluble NCAM -- NCAM, Synapses, Emotions, and Memory -- Role of NCAM in Spine Dynamics and Synaptogenesis -- NCAM in Long-Term Potentiation and Learning -- Role of NCAM in Emotion and Learning -- NCAM in Disease -- NCAM in Neuropsychiatric and Neurodegenerative Disorders -- Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms -- Pharmacology of NCAM: NCAM Mimetics -- NCAM Mimetic Peptides: An Update -- Synthetic NCAM-Derived Ligands of the Fibroblast Growth Factor Receptor -- Dendritic Spine and Synapse Morphological Alterations Induced by a Neural Cell Adhesion Molecule Mimetic -- Orthologs and Paralogs of NCAM -- Fasciclin II: The NCAM Ortholog in Drosophila melanogaster -- The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM -- Conclusion -- Honoring Dr. Elisabeth Bock.
520			_aAdhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. Structure and Function of the Neural Cell Adhesion Molecule NCAM describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aNeurosciences.
650		0	_aNeurochemistry.
650		0	_aNeurobiology.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aHuman Physiology.
650	2	4	_aNeurobiology.
650	2	4	_aNeurochemistry.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441911698
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v663
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-1170-4
596			_a19
942			_cLIBRO_ELEC
999			_c199148 _d199148