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008 100728s2010 xxu| s |||| 0|eng d
020 _a9781441916648
_9978-1-4419-1664-8
040 _cMX-MeUAM
050 4 _aR-RZ
082 0 4 _a610
_223
100 1 _aBalogh, Katalin.
_eeditor.
245 1 0 _aSuperMEN1
_h[recurso electrónico] :
_bPituitary, Parathyroid and Pancreas /
_cedited by Katalin Balogh, Attila Patocs.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v668
505 0 _aMEN1 Clinical Background -- Genetic Background of MEN1: From Genetic Homogeneity to Functional Diversity -- Menin: The Protein Behind the MEN1 Syndrome -- Cellular Functions of Menin -- The Role of Menin in Hematopoiesis -- Role of Menin in Bone Development -- Activin, TGF-? and Menin in Pituitary Tumorigenesis -- The Role of Menin in Parathyroid Tumorigenesis -- Role of Menin in Neuroendocrine Tumorigenesis -- Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis -- Functional Studies of Menin through Genetic Manipulation of the Men1 Homolog in Mice.
520 _aThe vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
700 1 _aPatocs, Attila.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441916624
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v668
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-1664-8
596 _a19
942 _cLIBRO_ELEC
999 _c199285
_d199285