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008 | 100728s2010 xxu| s |||| 0|eng d | ||
020 |
_a9781441916648 _9978-1-4419-1664-8 |
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040 | _cMX-MeUAM | ||
050 | 4 | _aR-RZ | |
082 | 0 | 4 |
_a610 _223 |
100 | 1 |
_aBalogh, Katalin. _eeditor. |
|
245 | 1 | 0 |
_aSuperMEN1 _h[recurso electrónico] : _bPituitary, Parathyroid and Pancreas / _cedited by Katalin Balogh, Attila Patocs. |
264 | 1 |
_aNew York, NY : _bSpringer New York, _c2010. |
|
300 | _bonline resource. | ||
336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v668 |
|
505 | 0 | _aMEN1 Clinical Background -- Genetic Background of MEN1: From Genetic Homogeneity to Functional Diversity -- Menin: The Protein Behind the MEN1 Syndrome -- Cellular Functions of Menin -- The Role of Menin in Hematopoiesis -- Role of Menin in Bone Development -- Activin, TGF-? and Menin in Pituitary Tumorigenesis -- The Role of Menin in Parathyroid Tumorigenesis -- Role of Menin in Neuroendocrine Tumorigenesis -- Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis -- Functional Studies of Menin through Genetic Manipulation of the Men1 Homolog in Mice. | |
520 | _aThe vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . . | ||
650 | 0 | _aMedicine. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
700 | 1 |
_aPatocs, Attila. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781441916624 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v668 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-1664-8 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c199285 _d199285 |