000			03921nam a22004455i 4500
001			u371431
003			SIRSI
005			20160812080128.0
007			cr nn 008mamaa
008			100316s2010 xxu| s |||| 0|eng d
020			_a9781441917706 _9978-1-4419-1770-6
040			_cMX-MeUAM
050		4	_aRC261-271
082	0	4	_a614.5999 _223
100	1		_aEnders, Greg H. _eeditor.
245	1	0	_aCell Cycle Deregulation in Cancer _h[recurso electrónico] / _cedited by Greg H. Enders.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aVIII, 206p. 19 illus., 11 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Cancer Research
505	0		_aStarting the Cell Division Cycle -- Escape from Cellular Quiescence -- Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription -- Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs -- Proliferation Under Duress -- Mitotic Checkpoint and Chromosome Instability in Cancer -- Mitotic Catastrophe -- p53, ARF, and the Control of Autophagy -- Long-Term Proliferation -- Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells -- Maintenance of Telomeres in Cancer -- The Senescence Secretome and Its Impact on Tumor Suppression and Cancer -- Applications in Preventing and Treating Cancer -- Cell Cycle Deregulation in Pre-neoplasia: Case Study of Barrett’s Oesophagus -- Targeting Cyclin-Dependent Kinases for Cancer Therapy.
520			_aModern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the cycle and partner with Cyclin dependent kinases (Cdks) to drive major cell cycle transitions. Much has been learned since about how these and other proteins control cell cycle progression in all eukaryotes, including man. Further research is uncovering how these controls are de-regulated in cancer, a disease of unbridled cell proliferation that is the leading cause of death in developed countries. However, there is much more to be learned, and the hard won gains are just beginning to impact cancer care. In 11 reviews by leading experts, this volume lays out the current state and directions of the field for biomedical scientists of all training levels. The collection begins with three reviews that delineate how cells initiate the cell cycle, from growth factor stimulation to activation of key transcription programs and origins of DNA replication. The next three reviews address issues of proliferation under duress, including how derangement of mitotic checkpoints can lead to cell death or genetic instability and how recycling of intracellular molecules (autophagy) is regulated. The next three reviews address the special context of long-term proliferation—how it is regulated in stem cells, how it can erode telomeric structures on the tips of chromosomes, and how it can culminate in senescence. The last two reviews describe how cell cycle advances are beginning to touch patients, in the characterization of pre-malignant states and in cancer therapy.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aPharmacology/Toxicology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441917690
830		0	_aCurrent Cancer Research
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-1770-6
596			_a19
942			_cLIBRO_ELEC
999			_c199311 _d199311