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005			20160812080136.0
007			cr nn 008mamaa
008			101226s2010 xxu| s |||| 0|eng d
020			_a9781441960665 _9978-1-4419-6066-5
040			_cMX-MeUAM
050		4	_aR-RZ
082	0	4	_a610 _223
100	1		_aBecchetti, Andrea. _eeditor.
245	1	0	_aIntegrins and Ion Channels _h[recurso electrónico] : _bMolecular Complexes and Signaling / _cedited by Andrea Becchetti, Annarosa Arcangeli.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXX, 124p. 23 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v674
505	0		_aIntegrin Structure and Functional Relation with Ion Channels -- to Ion Channels -- Biochemical Methods to Study the Interactions Between Integrins and Ion Channels -- Optical Methods in the Study of Protein-Protein Interactions -- Integrins and Signal Transduction -- Physical and Functional Interaction between Integrins and hERG1 Channels in Cancer Cells -- Coordinated Regulation of Vascular Ca2+ and K+ Channels by Integrin Signaling -- Adhesion-Dependent Modulation of Macrophage K+ Channels -- Integrin Receptors and Ligand-Gated Channels -- Integrins and Ion Channels in Cell Migration: Implications for Neuronal Development, Wound Healing and Metastatic Spread.
520			_aInterdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.
650		0	_aMedicine.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
700	1		_aArcangeli, Annarosa. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441960658
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v674
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-6066-5
596			_a19
942			_cLIBRO_ELEC
999			_c199452 _d199452