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001 u371593
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007 cr nn 008mamaa
008 120403s2010 xxu| s |||| 0|eng d
020 _a9781441961990
_9978-1-4419-6199-0
040 _cMX-MeUAM
050 4 _aR-RZ
082 0 4 _a610
_223
100 1 _aPoon, Randy Y. C.
_eeditor.
245 1 0 _aPolyploidization and Cancer
_h[recurso electrónico] /
_cedited by Randy Y. C. Poon.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _aXV, 151 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v676
505 0 _aPolyploidy, Aneuploidy and the Evolution of Cancer -- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability -- Understanding Cytokinesis Failure -- DNA Damage and Polyploidization -- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization -- Centrosomes, Polyploidy and Cancer -- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells -- Polyploidization of liver cells -- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry.
520 _aLimiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441961983
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v676
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-6199-0
596 _a19
942 _cLIBRO_ELEC
999 _c199473
_d199473