000 | 02818nam a22004335i 4500 | ||
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001 | u372037 | ||
003 | SIRSI | ||
005 | 20160812080201.0 | ||
007 | cr nn 008mamaa | ||
008 | 110713s2010 xxu| s |||| 0|eng d | ||
020 |
_a9781441978233 _9978-1-4419-7823-3 |
||
040 | _cMX-MeUAM | ||
050 | 4 | _aR-RZ | |
082 | 0 | 4 |
_a610 _223 |
100 | 1 |
_aGroßhans, Helge. _eeditor. |
|
245 | 1 | 0 |
_aRegulation of microRNAs _h[recurso electrónico] / _cedited by Helge Großhans. |
264 | 1 |
_aNew York, NY : _bSpringer US, _c2010. |
|
300 |
_aXVI, 160p. 35 illus., 6 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v700 |
|
505 | 0 | _amicroRNA Biogenesis and Function -- Regulation of pri-miRNA Processing Through Smads -- Stimulation of pri-miR-18a Processing by hnRNP A1 -- KSRP Promotes the Maturation of a Group of miRNA Precuresors -- Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor -- Autoregulatory Mechanisms Controlling the Microprocessor -- Regulation of pre-miRNA Processing -- The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function -- miRNAs Need a Trim -- Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression -- Turnover of Mature miRNAs and siRNAs in Plants and Algae -- MicroRNases and the Regulated Degradation of Mature Animal miRNAs. | |
520 | _aGiven this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aHuman genetics. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
650 | 2 | 4 | _aHuman Genetics. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781441978226 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v700 |
|
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-7823-3 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c199917 _d199917 |