000			03330nam a22004215i 4500
001			u372042
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005			20160812080201.0
007			cr nn 008mamaa
008			110628s2010 xxu| s |||| 0|eng d
020			_a9781441978417 _9978-1-4419-7841-7
040			_cMX-MeUAM
050		4	_aR-RZ
082	0	4	_a610 _223
100	1		_aJensen, Torben Heick. _eeditor.
245	1	0	_aRNA Exosome _h[recurso electrónico] / _cedited by Torben Heick Jensen.
264		1	_aNew York, NY : _bSpringer US, _c2010.
300			_aXVI, 144p. 26 illus., 11 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v702
505	0		_aFinding the Exosome -- Structural Components and Architectures of RNA Exosomes -- The Archaeal Exosome -- The Exosomes of Trypanosomes and Other Protists -- The Exosome and 3?–5? RNA Degradation in Plants -- Catalytic Properties of the Eukaryotic Exosome -- Functions of the Cytoplasmic Exosome -- Rrp6, Rrp47 and Cofactors of the Nuclear Exosome -- The Exosome and Heterochromatin -- Control of Cryptic Transcription in Eukaryotes -- The Human Exosome and Disease.
520			_aThe diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.
650		0	_aMedicine.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aMolecular Medicine.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441978400
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v702
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-7841-7
596			_a19
942			_cLIBRO_ELEC
999			_c199922 _d199922