000 | 03916nam a22004695i 4500 | ||
---|---|---|---|
001 | u372186 | ||
003 | SIRSI | ||
005 | 20160812084046.0 | ||
007 | cr nn 008mamaa | ||
008 | 110429s2011 xxu| s |||| 0|eng d | ||
020 |
_a9781441988195 _9978-1-4419-8819-5 |
||
040 | _cMX-MeUAM | ||
050 | 4 | _aQH301-705 | |
082 | 0 | 4 |
_a570 _223 |
100 | 1 |
_aHorvath, Steve. _eauthor. |
|
245 | 1 | 0 |
_aWeighted Network Analysis _h[recurso electrónico] : _bApplications in Genomics and Systems Biology / _cby Steve Horvath. |
264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2011. |
|
300 |
_aXXIII, 421 p. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
505 | 0 | _aPreface -- Networks and fundamental concepts -- Approximately factorizable networks -- Different type of network concepts -- Adjacency functions and their topological effects -- Correlation and gene co-expression networks -- Geometric interpretation of correlation networks using the singular value decomposition -- Constructing networks from matrices -- Clustering Procedures and module detection -- Evaluating whether a module is preserved in another network -- Association and statistical significance measures -- Structural equation models and directed networks -- Integrated weighted correlation network analysis of mouse liver gene expression data -- Networks based on regression models and prediction methods -- Networks between categorical or discretized numeric variables -- Networks based on the joint probability distribution of random variables -- Index. | |
520 | _aThis book presents state-of-the-art methods, software and applications surrounding weighted networks. Most methods and results also apply to unweighted networks. Although aspects of weighted network analysis relate to standard data mining methods, the intuitive network language and analysis framework transcend any particular analysis method. Weighted networks give rise to data reduction methods, clustering procedures, visualization methods, data exploratory methods, and intuitive approaches for integrating disparate data sets. Weighted networks have been used to analyze a variety of high dimensional genomic data sets including gene expression-, epigenetic-, methylation-, proteomics-, and fMRI- data. Chapters explore the fascinating topological structure of weighted networks and provide geometric interpretations of network methods. Powerful systems-level analysis methods result from combining network- with data mining methods. The book not only describes the WGCNA R package but also other software packages. Weighted gene co-expression network applications, real data sets, and exercises guide the reader on how to use these methods in practice, e.g. in systems-biologic or systems-genetic applications. The material is self-contained and only requires a minimum knowledge of statistics. The book is intended for students, faculty, and data analysts in many fields including bioinformatics, computational biology, statistics, computer science, biology, genetics, applied mathematics, physics, and social science. | ||
650 | 0 | _aLife sciences. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aBioinformatics. | |
650 | 0 | _aBiological models. | |
650 | 0 |
_aBiology _xData processing. |
|
650 | 1 | 4 | _aLife Sciences. |
650 | 2 | 4 | _aSystems Biology. |
650 | 2 | 4 | _aBioinformatics. |
650 | 2 | 4 | _aHuman Genetics. |
650 | 2 | 4 | _aComputer Appl. in Life Sciences. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781441988188 |
856 | 4 | 0 |
_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-4419-8819-5 |
596 | _a19 | ||
942 | _cLIBRO_ELEC | ||
999 |
_c200066 _d200066 |