000			03530nam a22004455i 4500
001			u372496
003			SIRSI
005			20160812084101.0
007			cr nn 008mamaa
008			100316s2010 xxu| s |||| 0|eng d
020			_a9781597453844 _9978-1-59745-384-4
040			_cMX-MeUAM
050		4	_aRC705-779
082	0	4	_a616.2 _223
100	1		_aMcCormack, Francis X. _eeditor.
245	1	0	_aMolecular Basis of Pulmonary Disease _h[recurso electrónico] : _bInsights from Rare Lung Disorders / _cedited by Francis X. McCormack, Ralph J. Panos, Bruce C. Trapnell.
264		1	_aTotowa, NJ : _bHumana Press, _c2010.
300			_aXI, 438 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aRespiratory Medicine
505	0		_aA Clinical Approach to Rare Lung Diseases -- Clinical Trials for Rare Lung Diseases -- Idiopathic and Familial Pulmonary Arterial Hypertension -- Lymphangioleiomyomatosis -- Autoimmune Pulmonary Alveolar Proteinosis -- Mutations in Surfactant Protein C and Interstitial Lung Disease -- Hereditary Haemorrhagic Telangiectasia -- Hermansky–Pudlak Syndrome -- Alpha-1 Antitrypsin Deficiency -- The Marfan Syndrome -- Surfactant Deficiency Disorders: SP-B and ABCA3 -- Pulmonary Capillary Hemangiomatosis -- Anti-glomerular Basement Disease: Goodpasture’s Syndrome -- Primary Ciliary Dyskinesia -- Pulmonary Alveolar Microlithiasis -- Cystic Fibrosis -- Pulmonary Langerhans’ Cell Histiocytosis – Advances in the Understanding of a True Dendritic Cell Lung Disease -- Sarcoidosis -- Scleroderma Lung Disease.
520			_aThe study of rare lung disorders enhances our understanding of common pulmonary diseases such as fibrosis and emphysema. Molecular Basis of Pulmonary Disease: Insights from Rare Lung Disorders brings together a panel of distinguished clinicians and molecular scientists who are experts in a range of rare lung diseases and their underlying molecular defects. Each chapter focuses on the pathogenic mechanisms and therapeutic targets suggested by basic research and follows an easy-to-read format: brief introduction followed by discussion of epidemiology, genetic basis and molecular pathogenesis, animal models, clinical presentation, diagnostic approaches, conventional management and treatment strategies, as well as future therapeutic targets and directions. Disorders ranging from the Marfan and Goodpasture’s syndromes to Sarcoidosis and alpha one antitrypsin deficiency are treated in detail. Written for pulmonary clinicians and scientists alike, Molecular Basis of Pulmonary Disease: Insights from Rare Lung Disorders is a comprehensive and invaluable nesource that sheds new light on the molecular mechanisms influencing the clinical presentation and treatment strategies for these debilitating disorders.
650		0	_aMedicine.
650		0	_aPneumology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPneumology/Respiratory System.
700	1		_aPanos, Ralph J. _eeditor.
700	1		_aTrapnell, Bruce C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588299635
830		0	_aRespiratory Medicine
856	4	0	_zLibro electrónico _uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-59745-384-4
596			_a19
942			_cLIBRO_ELEC
999			_c200376 _d200376