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020 _a9781603275149
_9978-1-60327-514-9
040 _cMX-MeUAM
050 4 _aRC321-580
082 0 4 _a612.8
_223
100 1 _aGadoth, Natan.
_eeditor.
245 1 0 _aOxidative Stress and Free Radical Damage in Neurology
_h[recurso electrónico] /
_cedited by Natan Gadoth, Hans Hilmar Göbel.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2011.
300 _aVIII, 323 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aOxidative Stress in Applied Basic Research and Clinical Practice
505 0 _a1. The role of free radicals in the nervous system -- 2. Why is the nervous tissue vulnerable to oxidative stress?- 3. Free radicals in perinatal hypoxic-ischemic encephalopathy: A fine balance -- 4. Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy -- 5. Oxidative stress in multiple sclerosis pathology and therapeutic potential of Nrf2 activation -- 6. Free Radicals in Central Nervous System -- 7. The Role of Reactive Oxygen Species in the Pathogenesis of Traumatic Brain Injury -- 8. Distinct roles of cyclooxygenases-1 and -2 in inflammatory and excitotoxic brain injury -- 9 . Stroke and Oxidative Stress -- 10. Free Radicals in Epilepsy -- 11. Neurological disorders associated with iron misdistribution: The therapeutic potential of siderophores -- 12. Oxidative stress in Parkinson's disease -- 13. Tetrahydrobiopterin Deficiency -- 14. Radicals Attack the Ear .The Toll: A Loss of Hearing -- 15. Mitochondrial Encephalomyopathies -- 16. Potential role of oxidative damage in neurological manifestations of acute intermittent porphyria. Pischik E and Kauppinen R.
520 _aThe role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aCell Biology.
650 2 4 _aMolecular Medicine.
700 1 _aGöbel, Hans Hilmar.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781603275132
830 0 _aOxidative Stress in Applied Basic Research and Clinical Practice
856 4 0 _zLibro electrónico
_uhttp://148.231.10.114:2048/login?url=http://link.springer.com/book/10.1007/978-1-60327-514-9
596 _a19
942 _cLIBRO_ELEC
999 _c200419
_d200419